糖皮质激素致儿童股骨头坏死1 例并高危因素文献分析

李贝贝; 姜志虎; 孙华君; 李志玲; 刘红霞

doi:10.13407/ j.cnki.jpp.1672.108X.2022.04.005

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糖皮质激素致儿童股骨头坏死1 例并高危因素文献分析

论著 | 更新时间：2022-11-03

- 糖皮质激素致儿童股骨头坏死1 例并高危因素文献分析
- Glucocorticoid-Induced Avascular Necrosis of Femoral Head in Children: a Case Report and Analysis of High Risk Factors
- 儿科药学杂志 2022年28卷第4期页码：15-18
- 作者机构：
  
  1. 上海市儿童医院,上海交通大学附属儿童医院,上海,200062
  2. 湖北医药学院附属襄阳市第一人民医院,湖北,襄阳,441000
- 作者简介：
- 基金信息：
- DOI：10.13407/ j.cnki.jpp.1672.108X.2022.04.005
  中图分类号：
- 纸质出版日期：2022，
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李贝贝, 姜志虎, 孙华君, 等. 糖皮质激素致儿童股骨头坏死1 例并高危因素文献分析[J]. 儿科药学杂志, 2022,28(4):15-18.

Li Beibei, Jiang Zhihu, Sun Huajun, et al. Glucocorticoid-Induced Avascular Necrosis of Femoral Head in Children: a Case Report and Analysis of High Risk Factors[J]. 2022,28(4):15-18.
李贝贝, 姜志虎, 孙华君, 等. 糖皮质激素致儿童股骨头坏死1 例并高危因素文献分析[J]. 儿科药学杂志, 2022,28(4):15-18. DOI： 10.13407/ j.cnki.jpp.1672.108X.2022.04.005.

Li Beibei, Jiang Zhihu, Sun Huajun, et al. Glucocorticoid-Induced Avascular Necrosis of Femoral Head in Children: a Case Report and Analysis of High Risk Factors[J]. 2022,28(4):15-18. DOI： 10.13407/ j.cnki.jpp.1672.108X.2022.04.005.

摘要

目的:探讨儿童激素性股骨头坏死的高危因素及预防儿童激素性股骨头坏死的药学干预措施。方法:回顾分析1 例长期大剂量使用糖皮质激素(GC)引发股骨头坏死的病例

通过查阅文献对患者的年龄、性别、激素使用剂量、基因多态性等因素进行分析

探讨患儿发生激素性股骨头坏死的高危因素以及预防儿童激素性股骨头坏死的药学干预措施。结果:年龄>10 岁、每日使用大剂量激素治疗、接受激素冲击治疗是发生激素性股骨头坏死的高危因素。基因多态性与激素性股骨头坏死的相关性研究仍缺乏定论。为减少激素性股骨头坏死的发生

对于存在高危因素的患者应注意进行钙剂和维生素D 的补充

必要时可考虑联用双磷酸盐预防治疗

但应注意进行相关的评估和用药监测。结论:年龄和糖皮质激素使用剂量是儿童激素性股骨头坏死的高危因素

对于存在高危因素的患者

应注意钙剂、维生素D 以及双磷酸盐的补充。

Abstract

Objective: To probe into the high risk factors for steroid-induced avascular necrosis of femoral head in children and order to reduce the incidence of steroid-induced avascular necrosis of femoral head

patients with high risk factors should be supplemented with calcium and vitamin D

if necessary

bisphosphonate prophylaxis were supposed to be considered. However

attention should be paid to relevant assessment and medication monitoring. Conclusion: Age and daily dose of glucocorticoid are high risk factors for steroid鄄induced avascular necrosis of femoral head in children. For patients with high risk factors

calcium

vitamin D and bisphosphonate supplementation are necessary. [Keywords]glucocorticoid; avascular necrosis of pharmaceutical intervention measures for prevention of steroid鄄induced avascular necrosis of femoral head in children. Methods: A case of long鄄term high鄄dose glucocorticoid (GC)鄄induced avascular necrosis of femoral head was retrospectively analyzed. The age

gender

daily dose of glucocorticoid

genetic polymorphism were analyzed by retrieving the literature to explore the high risk factors for steroid- induced avascular necrosis of femoral head in children and pharmaceutical intervention measures for prevention. Results: Age >10 years

high daily dose of glucocorticoid

and glucocorticoid pulse therapy were high risk factors for steroid鄄induced avascular necrosis of femoral head. Correlation between gene polymorphism and steroid-induced avascular necrosis of femoral head was still inconclusive. In pharmaceutical intervention measures for prevention of steroid鄄induced avascular necrosis of femoral head in children. Methods: A case of long-term high-dose glucocorticoid (GC)-induced avascular necrosis of femoral head was retrospectively analyzed. The age

gender

daily dose of glucocorticoid

high daily dose of glucocorticoid

and glucocorticoid pulse therapy were high risk factors for steroid-induced avascular necrosis of femoral head. Correlation between gene polymorphism and steroid-induced avascular necrosis of femoral head was still inconclusive. In

关键词

糖皮质激素股骨头坏死高危因素儿童

Keywords

glucocorticoavascular necrosis of femoral heahigh risk factorschildren

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